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Over time, this may help reduce the appearance of dark spots and uneven patches, leading to a more even-looking complexion

However, despite these interventions, clinical outcomes remain suboptimal: approximately 30%40% of diabetic foot ulcers fail to heal within 20 weeks of standard care, and the 5-year mortality rate following amputation exceeds 70% ( The impairment of DW healing is a multifactorial, multi-stage pathological process involving hyperglycemia, accumulation of advanced glycation end products (AGEs), oxidative stress, persistent inflammation, impaired angiogenesis, neuropathy, and increased infection risk (Peng et al., 2023) (Table 1)

IGF-1 is needed for normal growth

Eating protein is known to up-regulate it

How This Works IGF-1 LR3 is a synthetic analog of human insulin-like growth factor-1 engineered with an N-terminal extension (13 amino acids) and a glutamic acid substitution at position 3, resulting in significantly reduced binding affinity to IGF binding proteins [1]